The predictive value of the hepatorenal index for detection of impaired glucose metabolism in patients with non-alcoholic fatty liver disease

Avramovski, Petar and Avramovska, Maja and Nikleski, Zorica and Ilkovska, Biljana and Sotiroski, Kosta and Sikole, Emilija (2019) The predictive value of the hepatorenal index for detection of impaired glucose metabolism in patients with non-alcoholic fatty liver disease. Indian Journal of Gastroenterology, 39 (17). pp. 50-59. ISSN 0975 - 0711

Text 20. (2020) INDIAN J GASTROENTER, The predictive value of HRI for detection of imapired glucose metabolism...pdf - Accepted Version Download (1MB)

Abstract

Background/Purpose Non-alcoholic fatty liver disease (NAFLD) patients are at increased risk of liver-related as well as cardiovascular
mortality, including diabetes, coronary heart disease, and stroke, independently of traditional cardiovascular risk factors
and metabolic syndrome. The aim of this study was to find out the predictive impact of hepatorenal index (HRI) in the detection
of impaired glucose metabolism in asymptomatic NAFLD patients.
Methods B-mode ultrasound examinations were performed and ultrasound images from all 89 NAFLD patients aged 50.8 ±
10.1 years were analyzed by echogenicity analyzing software and HRI was acquired, and appropriate laboratory tests for liver,
glucose, and lipid metabolism were undertaken.
Results The mean HRI was 1.345 ± 0.189. 23.59% of patients had mild NAFLD (HRI = 1.167 ± 0.041), 64.04% moderate
(HRI = 1.401 ± 0.102), and 12.36% patients severe NAFLD (HRI = 1.802 ± 0.098). Impaired glucose metabolism was present
in 48.31% of patients. A positive correlation was present between HRI and impaired glucose metabolism (r = 0.335, p = 0.001).
The coefficients of determinations R2 for linear regression for HRI and glycated hemoglobin (HbA1c) and oral glucose tolerance
test (GTT) were 0.05841 and 0.07498, respectively. The cutoff values for HRI in the detection of diabetes and prediabetes, and
prediabetes only, were 1.4 and 1.38, respectively. In logistic regression, the β coefficients for oral GTT, HbA1c, or HRI were
0.62042 (p = 0.0002), 2.18036 (p = 0.0033), and 2.36986 (p = 0.012). The hazard ratio (HR) coefficients (exp [b]) for HRI, HbA1c, and oral GTT sorted according to their HR strength were 10.6958, 8.8494, and 1.8597, respectively.
Conclusion Ultrasonographically acquired HRI has a significant predictive impact on the detection of prediabetes and diabetes in
patients with NAFLD.
Keywords Diabetes . Hepatorenal index . Non-alcoholic fatty liver disease . Ultrasonography

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	27 May 2024 05:59
Last Modified:	27 May 2024 05:59
URI:	https://eprints.uklo.edu.mk/id/eprint/9924

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