Bone Mineral Density as Risk Factor for Bone Fractures

Avramovski, Petar and Avramovska, Maja and Sikole, Emilija (2017) Bone Mineral Density as Risk Factor for Bone Fractures. EC Orthopaedics, 7 (4). pp. 1-9.

Text 10. (2017) EC ORTHOPAEDICS, Bone mineral density and risk for fractures.pdf - Published Version Download (1MB)

Abstract

Osteoporosis is characterized by low bone mineral density (BMD) and bone microarchitectural deterioration. BMD is measured
with dual x-ray absorptiometry (DXA). The aim of this study is to determine the importance of BMD and T-score in predicting bone
fracture risk in patients sustained a minimal trauma fracture (MTF) of the hip. DXA estimation was conducted on 42 patients accompanied
by 5-year follow-up period with result of 10 MTFs. The mean and SD value for hip BMD was 0.897 ± 0.132 g/cm2 and T
- score was -0.733 ± 1.179. In logistic regression we found more predictable value for BMD than T – score (β coefficient = -14.429, P =
0.0092). Sensitivity/specificity pair (91.4%/93.75%), BMD cutoff value = 0.793 and Youden index generated by BMD receiver operating
characteristics (ROC) curve are more predictable in detection of hip MTF (P = 0.3464) than T - score sensitivity/specificity pair
(82% and 53.13%). By ROC curve we found no statistical significance between pairwise comparison of both Area Under Curve (AUC)
(0.838 and 0.769 for hip BMD and hip T - score, respectively). We concluded that hip BMD has greater predictable value in prediction
of bone fracture risk than hip T - score in anteroposterior DXA estimation.
Keywords: Bone Mineral Density; DXA; T-Score; ROC; AUC

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Basic medicine Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	27 May 2024 05:56
Last Modified:	27 May 2024 05:56
URI:	https://eprints.uklo.edu.mk/id/eprint/9920

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