Do patients with rheumatoid arthritis have aorta stiffer than general population?

Avramovski, Petar and Avramovska, Maja and Arsovska, Nalbanti Marija and Nikolovski, Pece and Sikole, Emilija (2017) Do patients with rheumatoid arthritis have aorta stiffer than general population? The Egyptian Journal of Internal Medicine, 30 (3). pp. 145-153. ISSN 1110-7782

Text 13. (2018) EGYPT J INT MED, Do patients with RA have stiffer aorta.pdf - Published Version Download (1MB)

Abstract

Objective
The aim of this study was to compare the aortic stiffness in patients with rheumatoid
arthritis (RA) with the aortic stiffness in general population (GP) and to evaluate the
determinants of their stiffness.
Patients and methods
The study group consisted of 80 patients with RA and 71 matched GP. Pulse wave
velocity (PWV) was assessed by Doppler ultrasonography. Biochemical analyses
were conducted for serum using standard laboratory procedures.
Results
The mean PWV values were 7.687±1.03 versus 7.253±0.97 m/s in the patients with
RA and GP, respectively. The average coordination of PWV and RA duration (RAD)
variations is present by equation of linear regression: y=7.1309+0.0971x. By
multiple regression analysis, C-reactive protein, (βst=0.1096, P=0.0009), RAD
(βst=0.0917, P=0.0018), high-density lipoprotein cholesterol (βst=−1.0610,
P=0.0271), and cholesterol (βst=0.8491, P=0.0350) were independently
associated with PWV in the patients with RA. C-reactive protein (βst=0.1057,
P=0.0016), triglycerides (βst=0.1730, P=0.0117), low-density lipoprotein
cholesterol (βst=0.1467, P=0.0206), and cholesterol (βst=0.0305, P=0.0261)
were independently associated with PWV in the GP.
Conclusion
Arterial stiffness was more pronounced in the patients with RA than in the GP. The
independent determinants of arterial stiffness in both groups include traditional risk
factors. RAD is determinant in patients with RA only.
Keywords:
aortic stiffness, Doppler ultrasonography, pulse wave velocity, rheumatoid arthritis, traditional
risk factors

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	UKLO Network
Depositing User:	D-r Petar Avramovski
Date Deposited:	27 May 2024 05:55
Last Modified:	27 May 2024 05:55
URI:	https://eprints.uklo.edu.mk/id/eprint/9910

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