First trimester PRISCA screening for Down's syndrome and Edward's syndrome in unselected pregnancies - report of a 6 - years experience

Ilkovska, Biljana and Kotevska-Trifunova, Bisera and Avramovski, Petar (2023) First trimester PRISCA screening for Down's syndrome and Edward's syndrome in unselected pregnancies - report of a 6 - years experience. Med. pregled, 59 (1). pp. 31-34. ISSN 1312-2193

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Abstract

Introduction First-trimester combined screening based on maternal age (MA), fetal nuchal translucency thickness (NT) and the serum markers free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A provide effective screening for trisomy 18 and 21. The aim of this study was to evaluate the performance of the first trimester combined test for Down and Edward syndrome detection, also the aim of this study is to show the prevalence of chromosomal abnormalities in pregnant women in the first trimester of pregnancy in the second largest city with 100,000 inhabitants in Macedonia
Materials and methods This was a retrospective case-matched study involving pregnant women who were seen at the department of obstetrics and gynecology at the Clinical Hospital Bitola, between January 2016 to December 2021 year.
Results The participants comprised 2975 women who participated in the screening voluntarily, mostly Caucasian (97.8%) with singleton pregnancies. Among them, there were 165 cases of trisomy 21 and 50 cases of trisomy 18. The mean gestational age, maternal age, and maternal weight were 86 days, 28 years and 67 kg, respectively. There were 257 (9%) women >35 years of age and 54 (2%) women with multiple gestations – twins. The detection rates for trisomy 21 and trisomy 18 were 8% and 1%.
Conclusion First trimester screening for aneuploidy is a valuable tool for the obstetrician and indications and methods of screening have evolved over the last quarter century. The primary goal of first trimester screen is to identify higher risk women for fetal aneuploidy and give them the option to pursue diagnostic testing in a timely manner if desired.

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Basic medicine Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	30 Jan 2024 08:03
Last Modified:	30 Jan 2024 08:03
URI:	https://eprints.uklo.edu.mk/id/eprint/9348

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