VITAMIN D LEVELS IN PATIENTS WITH CHRONIC HEPATITIS B, CHRONIC HEPATITIS C, AND HEALTH CONTROLS

Ilkovska, Biljana and Kotevska-Trifunova, Bisera and Hristovska, Sandra VITAMIN D LEVELS IN PATIENTS WITH CHRONIC HEPATITIS B, CHRONIC HEPATITIS C, AND HEALTH CONTROLS. Journal of IMAB, 25 (2). pp. 2553-2558. ISSN 1312-773X

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Abstract

Purpose: Hepatitis B virus and Hepatitis C virus infection
are the most common cause of acute and chronic
hepatitis. Over the past decade, numerous studies reported
that patients with chronic liver disease, especially HCVpositive
and HBV-positive patients, have decreased
25(OH)D levels compared to healthy people.
The aim of the present study has been to establish
the incidence and severity of Vitamin D deficiency in a cohort
of Macedonian patients with chronic hepatitis B and
C and health controls.
Material/Methods: This pilot study was performed
in Clinical hospital in Bitola (R. Macedonia). The total
number of participants was 148, 103 of them were healthy
people, 23 were chronic hepatitis C, and 22 were chronic
hepatitis B patients. The serum was separated, and Vitamin
D levels, HBsAg and Anti HCV titers were measured by using
Abbot Architect platform.
Results: We established that the Macedonian population
suffers from a deficiency of vitamin D. Vitamin D
levels are lower in healthy women, and women with hepatitis
B and C compared with males. We found that Vitamin
D is significantly lower in patients with hepatitis B compared
to control group, but there is not a significant correlation
between this two groups, and we can clearly state
that HBV- infected patients are at high risk of Vitamin D
deficiency.
Conclusions: We confirmed that only 12% of all
examinated subjects (n = 145) had values of vitamin D
within normal limits. This indicates the need to consume
foods rich in Vitamin D, require higher sun exposure or vitamin
D supplementation should be recommended in
healthy people, patients with chronic hepatitis C and B.
Keywords: hepatitis B virus, hepatitis C vitus, vitamin
D, health controls,

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Basic medicine Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	30 Jan 2024 08:04
Last Modified:	30 Jan 2024 08:04
URI:	https://eprints.uklo.edu.mk/id/eprint/9339

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