SERUM HEPCIDIN REFERENCE RANGE, GENDER DIFFERENCES, MENOPAUSAL DEPENDENCE AND BIOCHEMICAL CORRELATES IN HEALTHY SUBJECTS

Ilkovska, Biljana and Kotevska-Trifunova, Bisera and Trifunov, Georgi and Kanazirev, Branimir (2016) SERUM HEPCIDIN REFERENCE RANGE, GENDER DIFFERENCES, MENOPAUSAL DEPENDENCE AND BIOCHEMICAL CORRELATES IN HEALTHY SUBJECTS. Journal of IMAB, 22 (2). pp. 1127-1131. ISSN 1312-773X

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Abstract

ABSTRACT:
Background: Hepcidin has emerged as the central
regulatory molecule of iron homeostasis. Iron deficiency and
iron overload play a major role in molecular insights of many
disease states and serum hepcidin normal values and biochemical
correlations are of substantial importance.
Objective: The aim of this study is to examine the
serum hepcidin reference range, gender and age differences,
menopausal dependence and biochemical correlates in
healthy subjects.
Methods: Serum hepcidin concentration was measured
with a competitive enzyme-linked immunosorbent assay
(DRG Hepcidin-25 ELISA Kit) together with
hemoglobin, hematocrit, serum iron, transferrin and C-reactive
protein in 120 healthy subjects both men and pre- and
post-menopausal women.
Results: Normal serum hepcidin values were found
in the range of 1,23 – 36,46 ng/mL (mean 9,25 ± 6,45 ng/
mL).There were statistically significant differences in measured
hepcidin levels between men (12,34 ± 7,37 ng/mL)
and women (6,16 ± 3,2 ng/mL) (p<0.01) and between premenopausal
(5,51 ± 2,8 ng/mL) and post-menopausal women
(7,29 ± 3,59 ng/mL) ( p<0,05). Strong correlations were
found with serum ferritin and hemoglobin but not with serum
iron, transferrin and CRP. No 5-year age interval differences
were deemed significant.
Conclusion: Serum hepcidin concentration varied
substantially between subjects, which is reflected in wide
reference ranges. Serum hepcidin levels were gender and
menopausal status related and were in correlation with
hemoglobin and serum ferritin in healthy subjects.
Key words: hepcidin, range, gender, menopause,
healthy subjects

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Basic medicine Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	30 Jan 2024 08:04
Last Modified:	30 Jan 2024 08:04
URI:	https://eprints.uklo.edu.mk/id/eprint/9337

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