Correlation between Alzheimer`s Disease and elevated Pulse Wave Velocity

Avramovski, Petar and Avramovska, Maja and Lazarevski, Miroslav and Doneva, Ana and Siklovska, Vesna (2022) Correlation between Alzheimer`s Disease and elevated Pulse Wave Velocity. In: The 3rd (virtual) European Conference on Neuroinflammation, 9-10 May 2022, London, UK.

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Abstract

Petar Avramovski1, 6 Maja Avramovska2, 7 Miroslav Lazarevski3 Ana Doneva4Vesna Siklovska5

1Internal Medicine, Clinical Hospital - Bitola, Republic of North Macedonia
2Gynceology and Obstetric, Clinical Hospital - Bitola, Republic of North Macedonia
3Internal Medicine, General City 8th September, Republic of North Macedonia
4Neurology, General City 8th September, Republic of North Macedonia
5Radiology, Clinical Hospital - Bitola, Republic of North Macedonia
6Internal Medicne, Clinical Hospital - Bitola, Republic of North Macedonia
7Gynceology and Obstetric, Clinical Hospital - Bitola, Republic of North Macedonia
Aims: The arterial stiffening is considered an important risk factor for Alzheimers disease. The Pulse Wave Velocity (PWV) is measure of arterial stiffness. The aim of this study was to find correlation between elevated PWV and Alzheimer`s disease.
Methods: PWV was calculated from time diversity propagation of the common carotid and femoral artery by Doppler ultrasound in 775 elderly patients with mean age of 71.2±8.7 years. The patients were divided into two groups: first (PWV > 10 m/s) and second (PWV ≤ 10 m/s).
Results: The mean PWV in total group was 10.12 m/s. In the first group (N = 315) was 11.73 m/s and in the second (N = 460) was 9.65 m/s. We diagnosed 13 (4.12%) cases and 4 (0.87%) of Alzheimer`s Disease in first and second group respectivelly (Chi-squared 9.204, P = 0.0024 (Confidence interval [CI] = 1.0841 % - 6.1032%), difference = 3.25% . The incidence of Alzheimer`s disease is 4.73 times higher in group with higher pulse velocity with cut-off value of 10 m/s. PWV strongly correlate with Alzheimer`s disease in first group (r = 0.145, P = 0.009) than in the second (r = 0.119, P = 0.034).
Conclusion: There is a statistically significant difference in artery stiffness in patients with or without Alzheimer`s disease. The incidence of this disease is 4.73 times higher in patients with arterial stiffness greater than the critical PWV (cut-off value 10 m/s). The PWV is in strong correlation with Alzheimer`s disease. Proving the predictive effect of arterial stiffness in the onset of Alzheimer`s disease requires additional studies.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Veterinary Medicine
Depositing User:	D-r Petar Avramovski
Date Deposited:	26 May 2023 09:16
Last Modified:	26 May 2023 09:16
URI:	https://eprints.uklo.edu.mk/id/eprint/8368

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