Arterial Stiffness in Pregnant with Non-Alcoholic Fatty Liver Disease During 4th to 31th Gestational Week Follow-Up: A Case Report of Preterm Birth

Avramovska, Maja and Popovski, Vlatko and Talev, Stefan and Stoilova, Snezana and Mladenovska, Mira and Sotiroski, Kosta and Sikloska, Vesna and Avramovski, Petar (2022) Arterial Stiffness in Pregnant with Non-Alcoholic Fatty Liver Disease During 4th to 31th Gestational Week Follow-Up: A Case Report of Preterm Birth. EC Gynaecology, 11 (8). pp. 37-43.

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Abstract

Introduction: There is a strong correlation between nonalcoholic fatty liver disease (NAFLD) and increased pulse wave velocity
(PWV) which is in association with hypertensive complication, postpartum hemorrhage and preterm birth. This is a case report of
PWV and NAFLD progressive changes, also laboratory markers in pregnant women during a 4th to 31th gestational week (g.w.) followup
period with preterm delivery.
Case Presentation: We found by ultrasonography (at 4 g.w.) a mild NAFLD according measured hepatorenal index (HRI) = 1.187
and elevated PWV = 6.37 cm/s in 32-year-old pregnant overweight woman [Body mass index (BMI) = 25.6 kg/m2] with accelerated
aminotransferases activity, and impaired glucose and lipid metabolism. The ultrasound examination performed at 31 g.w. found
increased BMI by 16%, PWV by 6.4% and HRI by 11.6%. Increased systolic/diastolic blood pressure (10.1%/22.7%) and impaired
metabolism of insulin, glucose and lipid were detected, too. The baby boy was born preterm, with normal 5-min and 10-min Apgar
score, in 36 g.w.
Conclusion: Increased PWV, NAFLD, impaired metabolism of glucose and lipids, high BMI, insulin resistance and gestational diabetes
are risk factors for the premature delivery. Early detection of NAFLD and PWV rise, blood pressure, lipid and glucose metabolism will
improve the mother’s and newborn’s health, and will also contribute to on term deliveries.

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	Rectorate
Depositing User:	D-r Petar Avramovski
Date Deposited:	13 Apr 2023 12:53
Last Modified:	13 Apr 2023 12:53
URI:	https://eprints.uklo.edu.mk/id/eprint/8012

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