Assessment of prognostic values of serum CEA and CA 19-9 concentration in patients with colorectal cancer

Tuteska, Jovanka and Arapcheska, Mila and Stojkovski, Velimir and Gligurovska, J (2019) Assessment of prognostic values of serum CEA and CA 19-9 concentration in patients with colorectal cancer. In: 23rd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine "EuroMedLab 2019", Barcelona.

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Abstract

Background-aim
The control of chemotherapy is one of the most important problems in oncological practice. Markers of biological activity of the tumor are used for assessment of therapy effect. Colorectal cancer is one of the most common causes of cancer related death worldwide. Tumor markers for colorectal cancer can be found in the blood or in the tumor tissue itself. CEA and CA19-9 are the most common tumor markers for colorectal cancer that are currently utilized clinically. Aim of this study was the assessment of the prognostic value of tumor markers CEA and CA19-9 in patients with colorectal cancer.

Methods
In the study were included patients with colorectal cancer who underwent surgery (n=70; males=40 and females=30, on age from (32 to 77 years). Serum samples were taken from patients before surgery; before the start and three months after chemotherapy. The serum values of CEA and CA 19-9 were measured by enzyme linked fluorescent immunoassay using VIDAS analyzer.

Results
Obtained results indicated elevated values of CEA in 86% of male and 83% of female patients (14% male and 17% female had normal CEA values according referent) and elevated values of CA 19-9 in 65% of male and 58% of female patients (35% male and 42% female had normal CA 19-9 values) before surgery. The results have shown significant difference between preoperative and postoperative values of serum CEA and CA 19-9 (p<0.001). According results the concentration of CEA was higher (4.86%) in patients after chemotherapy than before its start, while concentration of CA 19-9 was higher (19.58%) in patients before start of chemotherapy. However statistical analysis of obtained results did not shows significant differences in values of CEA and CA 19-9 before start and three months after chemotherapy. 56% of patients had survival period less than two years.

Conclusions
Tumor markers play a crucial role in detecting disease and in assessment of response to therapy. Mainly, changes of serum levels of tumor markers correlate with therapy effect. The effect of treatment on tumor proliferation can be successfully estimated by decreasing tumor marker levels.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Scientific Fields (Frascati) > Natural sciences > Biological sciences Scientific Fields (Frascati) > Natural sciences > Other natural sciences
Divisions:	Faculty of Biotechnical Sciences
Depositing User:	Prof. d-r Mila Arapceska
Date Deposited:	08 Mar 2021 21:12
Last Modified:	08 Mar 2021 21:12
URI:	https://eprints.uklo.edu.mk/id/eprint/6293

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