Pavlova, Valentina and Menkinoska, Marija and Blazevska, Tatjana and Gjorgovska, N. (2014) HPLC method for determination of some psychostimulative drugs using derivatization reagent. Horizons-series B. pp. 173-182. ISSN 1857-8578
Full text not available from this repository.Abstract
Different alternatives for the rapid and sensitive determination of some
psychostimulative drugs (MDA, MDMA, MDEA, MBDB), by Highperformance liquid chromatography (HPLC) have been evaluated. The
method involved derivatization with 3,5-dinitrobenzoylchloride at ambient
temperature and separation of the derivatives formed on a Lichrospher® 60
RP-select B, 5 µm, 250 x 4,6 mm id column protected by appropriate guard
column. Conditions for the derivatization have been investigated, including
the pH, the reaction time and the derivatization reagent concentration. After
optimisation, the best results obtained using buffer with pH 10.0, reaction
time 5 min and concentration of derivatization reagent 5 mmol/L.
Key words: determination, psychostimulative drugs, derivatization, Highperformance liquid chromatography
| Item Type: | Article |
|---|---|
| Subjects: | Scientific Fields (Frascati) > Natural sciences > Chemical sciences |
| Divisions: | Faculty of Technology and Technical Sciences |
| Depositing User: | Mr Jordan Martinovski |
| Date Deposited: | 06 Feb 2019 16:43 |
| Last Modified: | 07 Aug 2019 09:30 |
| URI: | https://eprints.uklo.edu.mk/id/eprint/1663 |
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