Effects of vitamin C and D supplementation on pulmonary function, symptoms and inflammatory parameters in non-obstructive chronic bronchitis

Marky, Flamur and Blazevska, Tatjana and Velkovski, Valentina and Antoska-Knights, Vesna and Gruevska, Nevena and Temelkovska Ristevska, Katerina and Gacoska Jankuloska, Kristina (2026) Effects of vitamin C and D supplementation on pulmonary function, symptoms and inflammatory parameters in non-obstructive chronic bronchitis. Proceedings of Second International Scientific Agri -  Business Conference.

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Abstract

Non-obstructive chronic bronchitis (NCB) is characterized by chronic productive cough without spirometric obstruction (FEV1/FVC ≥ 0.70), although patients often experience pronounced symptoms, functional impairment, and signs of systemic inflammation. Oxidative stress and immune
dysregulation play an important role in the pathophysiology of the disease, suggesting a potential benefit from antioxidant and immunomodulatory interventions. The aim is to assess the effects of high-dose vitamin C and vitamin D supplementation on pulmonary function, symptoms, functional capacity, and inflammatory status in patients with NCB. Material and Methods: In this cross-sectional
observational study, 62 adult patients with non-obstructive chronic bronchitis (NCB) were included
and divided into a control group (standard therapy) and an intervention group that additionally
received vitamin C (2 g/day) and vitamin D (100,000 IU monthly) for a period of six months. Symptom
burden was assessed using the COPD Assessment Test (CAT), functional capacity was evaluated using
the six-minute walk test (6MWD), and systemic inflammation was measured through serum C-reactive
protein (CRP). Group comparisons were analyzed using independent t-tests or Mann–Whitney U tests,
with a level of statistical significance set at p < 0.05. Results and discussion: Patients receiving vitamin
supplementation showed significantly lower CAT scores (p = 0.005), significantly greater 6MWD
distance (p = 0.003), and lower serum CRP levels (p = 0.044) compared to the control group. These
results indicate reduced symptom burden, improved functional capacity, and reduced systemic inflammation. Conclusion: Supplementation with high doses of vitamin C and D in patients with non-obstructive chronic bronchitis leads to significant improvement in symptoms, physical endurance, and
inflammatory status.

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Agricultural Sciences > Agricultural biotechnology Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences Scientific Fields (Frascati) > Engineering and Technology > Industrial biotechnology
Divisions:	Faculty of Technology and Technical Sciences
Depositing User:	Mr Jordan Martinovski
Date Deposited:	11 May 2026 12:52
Last Modified:	11 May 2026 12:52
URI:	https://eprints.uklo.edu.mk/id/eprint/11541

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