HISTOPATHOLOGICAL CHARACTERIZATION AND BIOLOGICAL ASSESSMENT OF TESTICULAR TUMORS IN DOGS WITH CRYPTORCHIDISM

Janevski, Dejan and Radinovic, Miodrag and Gichova, Tijana and Krivokapic, Jovana and Stanojevic, Jovan and Dameski, Pance and Zdraveski, Igor and Petrovska, Biljana and Dodovski, Petar and Gacovski, Zivko and Petrovska, Natasa (2025) HISTOPATHOLOGICAL CHARACTERIZATION AND BIOLOGICAL ASSESSMENT OF TESTICULAR TUMORS IN DOGS WITH CRYPTORCHIDISM. Veterinary Journal of Republic of Srpska, 25 (1-2). pp. 174-185.

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Abstract

Abstract: The descent of the testes (descensus testis) is a crucial process in the
embryonic development of male animals, the disruption of which results in
cryptorchidism—a condition representing a significant risk factor for the development
of testicular neoplasms. The aim of this study was to determine the prevalence, type,
and biological behavior of testicular tumors in dogs with confirmed cryptorchidism, as
well as their association with breed and age. The research encompassed a total of 311
biopsies of pathologically suspicious testes collected between September 2019 and
September 2024, of which 72 samples (23.15%) were diagnosed as tumors.
Histopathological analysis was performed using the standard hematoxylin-eosin (HE)
staining method. Of the total diagnosed tumors, 80.56% were benign and 19.44%
malignant, with metastases recorded in 42.86% of the malignant cases. The most
common tumor types were Leydig cell tumor (33.3%), seminoma (31.9%), and Sertoli
cell tumor (25%). The breed most frequently affected by benign tumors was the
Siberian Husky, while malignant tumors were most commonly observed in Boxers and
Siberian Huskies. The average age of dogs with tumors was 11 years. The results
indicate that cryptorchidism, in combination with age and breed predisposition,
significantly increases the risk of testicular tumor development in dogs.
Keywords: benign tumors, dogs, malignant tumors, testes

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Agricultural Sciences > Veterinary science
Divisions:	Faculty of Veterinary Medicine
Depositing User:	Mrs Natasha Petrovska
Date Deposited:	18 Mar 2026 11:19
Last Modified:	18 Mar 2026 11:19
URI:	https://eprints.uklo.edu.mk/id/eprint/11459

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