CURCUMIN AND ITS STRUCTURAL ANALOGUES: A REVIEW OF SYNTHETIC STRATEGIES, ANALYTICAL METHODS AND PHARMACOLOGICAL POTENCIAL

Lozanovski, Zlatko and Velkovski, Valentina and Jankulovska, Angelka and Petkovska, Daniela and Arsovski, Denis and Zivkovikj, Gabriel (2026) CURCUMIN AND ITS STRUCTURAL ANALOGUES: A REVIEW OF SYNTHETIC STRATEGIES, ANALYTICAL METHODS AND PHARMACOLOGICAL POTENCIAL. In: 1 International Scientific Conference - Food Science, Nutrition, Innovative Technologies st and Sustainability, 03.10.2025, Veles, North Macedonia.

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Abstract

Curcumin, a polyphenolic compound extracted from Curcuma longa, has attracted considerable attention for its traditional use in medicine and its wide-ranging biological activities. It has shown therapeutic potential in various conditions, including cancer, autoimmune diseases, metabolic disorders, neurodegenerative diseases, and chronic inflammation. However, despite its promising pharmacodynamic profile, curcumin’s clinical relevance remains limited due to its poor chemical stability and low bioavailability. These limitations stem primarily from its keto
enol tautomerism, rapid metabolism, poor water solubility, and the chemical reactivity of its β diketone and methylene groups. These electrophilic sites, although crucial for biological activity, also make the molecule highly unstable above pH 6.5, leading to rapid degradation in physiological environments. This review focuses on the exploration and critical evaluation of synthetic structure-based modelling strategies including the elimination of reactive sites (e.g.,
phenolic and enolic hydroxyl groups), the introduction of stabilizing functional groups, and the design of novel analogues with enhanced metabolic resistance and target selectivity. Special attention is given to derivatization approaches that improve chemical stability, solubility, and systemic delivery. Furthermore, emphasis is placed on the analytical characterization of these analogues through advanced techniques, including spectroscopic and chromatographic methods,
in order to validate their structural integrity and potential pharmacological relevance. Overall, the review highlights the potential of curcumin-derived scaffolds in drug development and supports further investigation into optimized analogues for clinical use.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Scientific Fields (Frascati) > Natural sciences > Chemical sciences
Divisions:	Higher Medical School
Depositing User:	MSc Denis Arsovski
Date Deposited:	13 Mar 2026 11:19
Last Modified:	13 Mar 2026 11:19
URI:	https://eprints.uklo.edu.mk/id/eprint/11449

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