Are systemic inflammatory markers linked to euthyroid nodular goiter?

Todorovska, Liljana and Avramovski, Petar and Avramovska, Maja and Todorovski, Jovan and Ilkovska, Biljana and Sotiroski, Kosta and Vaskova, Olivija (2025) Are systemic inflammatory markers linked to euthyroid nodular goiter? Rom J Diabetes Nutr Metab Dis, 32 (4). pp. 486-492. ISSN 1583-8609

Other (Manuscript, Original Article) 51. ===(2025) ROM J DIABETES, Are systemic inflammatory markers linked to goiter.pdf - Accepted Version Download (1MB)

Abstract

The role of systemic inflammatory markers (SIMs) in euthyroid nodular goiter (ENG) is unclear. This study evaluated their associations and predictive value for ENG in iodine-sufficient adults. Material and methods: In this prospective, case-control study, 212 euthyroid participants (20–60 years) underwent thyroid ultrasound. Laboratory evaluations included thyroid- stimulating hormone, free thyroxine, anti-thyroid peroxidase antibodies, C-reactive protein, and blood cell counts. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), and the systemic immune-inflammation index (SII) were calculated, with logarithmic SIRI [log (SIRI)] and square root SII [sqrt (SII)] transformations. Logistic regression and receiver operating characteristic (ROC) curve analysis were applied. Results: Mean age was 43±9 years (83% female). ENG (n=103) and controls (n=100) did not differ in age, thyroid function, autoimmunity, or SIMs. Age correlated with ENG (ρ=0.148, P=0.032). Log (SIRI) (positive)
and sqrt (SII) (inverse) were independent ENG predictors. ROC analysis confirmed log (SIRI) as the strongest, gender-independent predictor of ENG (an area under the curve=0.675, P<0.001; cut-off >0.760). SIRI was the strongest, gender-independent predictor of ENG, while SII was inversely associated.
Keywords: goiter, nodular, inflammation, markers, C-reactive protein

Item Type:	Article
Uncontrolled Keywords:	goiter, nodular, inflammation, markers, C-reactive protein
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences
Divisions:	UKLO Network
Depositing User:	D-r Petar Avramovski
Date Deposited:	17 Mar 2026 08:34
Last Modified:	17 Mar 2026 08:34
URI:	https://eprints.uklo.edu.mk/id/eprint/11437

Actions (login required)

View Item