EFFECTS OF NIACIN ON BLOOD INDICATORS OF LIPOMOBILIZATION AND HEPATIC FUNCTION IN DAIRY COWS DURING EARLY LACTATION

HRISTOVSKA, TALIJA and CINCOVIĆ, MARKO and Dodovski, Petar and Karabolovski, Nikola and Pejcinovska, Natasa and Dameski, Pance and Zdraveski, Igor and Ristevski, Mimi EFFECTS OF NIACIN ON BLOOD INDICATORS OF LIPOMOBILIZATION AND HEPATIC FUNCTION IN DAIRY COWS DURING EARLY LACTATION. Journal of Hygienic Engineering and Design.

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Abstract

During the first 2 weeks of lactation dairy cows
experience a negative energy balance. As a response
to the negative energy balance high degree of lipid
mobilization from the stored body fat occurs. When
niacin is administered in pharmacological doses, it has
an antilipolytic effect and reduces non-esterified fatty
acids release from adipose tissue. The present study
aimed to investigate the effect of pharmacological
doses of niacin on blood indicators of lipomobilization
and hepatic function in dairy cows during early
lactation.
The experiment included 30 Holstein-Friesian dairy
cows. The cows were allocated into two groups 15
cows in each (niacin and control group). Niacin was
administered per os with food in the dose of 120 grams
per day per cow, for 4 weeks, 2 weeks before and
after calving. Blood samples were taken three times:
on the day of calving, 7 and 14th day after calving.
Metabolic parameters non-esterified fatty acids, beta
hydroxybutyrate, glucose, triglyceride, cholesterol,
total protein, albumin, aspartate aminotransferase,
alkaline phosphatase, gamma-glutamyltransferase,
total bilirubin and urea were determined using
colorimetric reaction according to the manufacturer’s
instruction colorimetric test kits and were measured
using a semi-automatic analyzer. Differences in
metabolite concentration between the niacin and
control group of cows were determined. Two-way
ANOVA, Least Significant Difference, and Pearson
correlation were used for statistical analysis.
Correlation coefficients among the blood indicators of
lipomobilization (non-esterified fatty acids and beta
hydroxybutyrate) and the blood indicators of hepatic
lesion and function (aspartate aminotransferase,
alkaline phosphatase, gamma-glutamyl transferase,
glucose, cholesterol, albumin, total protein, urea, and
triglyceride) were calculated. Significant correlations
(p < 0.01) were observed in most of the parameters. We
found significantly lower aspartate aminotransferase
concentration in the niacin group compared to the
control group and this result indicates that cows that
received niacin had lower liver lesions and damage
because of decreased lipomobilization. A positive
correlation between indicators of lipomobilization and
hepatic enzymes was found.
Pharmacological doses of niacin supplemented daily
for 4 weeks suppress lipolysis and improve hepatic
function in dairy cows during the peripartal period.

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Agricultural Sciences > Veterinary science
Divisions:	Faculty of Veterinary Medicine
Depositing User:	Mr Aleksandar Lozanovski
Date Deposited:	30 Apr 2025 10:41
Last Modified:	30 Apr 2025 10:41
URI:	https://eprints.uklo.edu.mk/id/eprint/10912

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