Cognitive Function Variability and Health-related Quality of Life in Multiple Sclerosis: A Comprehensive Analysis Across Different Multiple Sclerosis Types

Arsovski, Denis and Jankulovska, Angelka and Petkovska, Daniela (2024) Cognitive Function Variability and Health-related Quality of Life in Multiple Sclerosis: A Comprehensive Analysis Across Different Multiple Sclerosis Types. Journal of Multiple Sclerosis Research, 4 (2). pp. 38-46. ISSN 2791-7851

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Abstract

Objective: To investigate cognitive function variability and health-related quality of life in patients with diverse types of multiple sclerosis (MS).
Materials and Methods: This study involved 780 participants diagnosed with various types of MS. Data was collected using the MS quality of life 54 questionnaire, administered online during the coronavirus disease-2019 pandemic.
Results: The cognitive function scores of the various MS types were found to be significantly distinct, with the relapsing-remitting (RR) type exhibiting the greatest variability. Repeated measures analysis of variance revealed a modest improvement in cognitive function over time in RRMS
patients. Age and health-related quality of life exhibited a highly significant negative correlation (r=-0.63, p<0.001). Heritability analysis suggested that approximately 45% of cognitive function variability is attributable to genetic factors. Specifically, RRMS patients exhibited higher cognitive function scores compared to patients with primary-progressive type and secondary-progressive type of MS (p<0.01 and p<0.05, respectively).
Conclusion: Cognitive function and health-related quality of life differ significantly among the different MS types. Age and genetic factors play critical roles in cognitive health. The findings underscore the need for conducting routine cognitive assessments in MS patients, especially for
those with RRMS, to provide early intervention and enhance patient outcomes. Comprehensive mean square care necessitates the integration of cognitive and physical health management strategies.
Keywords: Multiple sclerosis, cognitive dysfunction, quality of life, rehabilitation, mental health

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences Scientific Fields (Frascati) > Medical and Health Sciences > Other medical sciences
Divisions:	Higher Medical School
Depositing User:	MSc Denis Arsovski
Date Deposited:	09 Oct 2024 11:54
Last Modified:	09 Oct 2024 11:54
URI:	https://eprints.uklo.edu.mk/id/eprint/10333

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