ASPARTATE AMINOTRANSFERASE AND GAMMAGLUTAMYL TRANSFERASE: INTRIGUING CLINICAL BIOMARKERS IN DISCRIMINATION OF HEPATIC LESION BETWEEN HEPATITIS C INFECTED PATIENTS AND HEALTHY CONTROLS

Ilkovska, Biljana and Kotevska Trifunova, Bisera and Avramovska, Maja and Taleva, Biljana and Talev, Stefan and Sotiroski, Kosta and Avramovski, Petar (2023) ASPARTATE AMINOTRANSFERASE AND GAMMAGLUTAMYL TRANSFERASE: INTRIGUING CLINICAL BIOMARKERS IN DISCRIMINATION OF HEPATIC LESION BETWEEN HEPATITIS C INFECTED PATIENTS AND HEALTHY CONTROLS. Acta Clinica Croatica, 62 (4). pp. 688-696. ISSN 0353-9466 (In Press)

Text AST, ALT, hepatitis, Ilkovska avramovski.pdf - Accepted Version Download (503kB)

Abstract

SUMMARY – Over 1.5 million new cases of chronic hepatitis C virus (HCV) infection occur each year, infecting an estimated 58 million people worldwide. We aimed to find differences in peripheral blood count, liver enzymes and degradation products between HCV infected and healthy controls, and their impact on detection of the disease and discrimination of the diseased from non-diseased subjects.
We performed laboratory testing for peripheral blood count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (γ-GT) and bilirubin in 40 HCV patients and 40 healthy controls. There were statistically significant differences in leukocytes (p=0.001), ALT (p<0.0001), AST (p<0.0001), ALP (p<0.0001), γ-GT (p<0.0001), total bilirubin
(p<0.018) and indirect bilirubin (p<0.030) between the HCV infected and control groups. On multiple
regression, the independent variables of HCV titer (p=0.5091), granulocytes (p=0.7061) and total bilirubin
(p=0.2022) showed no impact on liver lesion estimated by a dependent variable of γ-GT. On logistic
regression, only AST [p=0.0112, odds ratio (OR)1.2161, area under the curve (AUC) 0.887] and γ-GT
(p=0.0283, OR 1.1041, AUC 0.815) showed a statistically significantly positive predicting value when
discriminating healthy subjects and diseased patients. In conclusion, HCV titer, granulocytes and total
bilirubin did not show a statistically significant impact on hepatic lesion expressed by γ-GT, whereas only
AST and γ-GT showed a statistically significant positive predicting value to discriminate infected patients
from healthy controls. Each unit increase in AST and γ-GT resulted in 21.6% and 10.4% higher possibility
for possible HCV infection, respectively.
Key words: Hepatitis C virus (HCV); Aspartate aminotransferase; Gamma-glutamyl transferase; HCV
titer; Liver enzymes

Item Type:	Article
Uncontrolled Keywords:	Hepatitis C virus (HCV), Aspartate aminotransferase, Gamma-glutamyl transferase, HCV titer, Liver enzymes.
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	07 Jun 2024 10:02
Last Modified:	07 Jun 2024 10:02
URI:	https://eprints.uklo.edu.mk/id/eprint/10042

Actions (login required)

View Item