Network Analysis of Structural Properties of Gene Regulatory Networks

Ristevski, Blagoj (2014) Network Analysis of Structural Properties of Gene Regulatory Networks. In: 3th International Workshop on Translational Bioinformatics and Health Informatics, May 21-23, 2014, Izmir, Turkey.

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Abstract

Genes interact mutually through RNA and proteins and with other metabolites, molecules and other complexes composing complex networks. These networks whose nodes representing protein-coding and microRNA genes are called gene regulatory networks. Including microRNA genes in reconstruction of gene regulatory networks can provide novel and very useful insights into the cells’ regulatory mechanisms. The analysis of network structural and graph theoretical properties are very important to expedite the study of various biological processes. In this work, global network properties such as diameter of graph, nodes’ degree distribution, centrality measures, clustering coefficient, network motifs and graphlets, are described. These properties are applied to particular gene regulatory networks in order to analyze biological network topology.

Item Type: Conference or Workshop Item (Paper)
Subjects: Scientific Fields (Frascati) > Natural sciences > Computer and information sciences
Scientific Fields (Frascati) > Engineering and Technology > Electrical engineering, electronic engineering,information engineering
Divisions: Faculty of Information and Communication Technologies
Depositing User: Prof. d-r. Blagoj Ristevski
Date Deposited: 24 Aug 2020 08:12
Last Modified: 24 Aug 2020 08:12
URI: http://eprints.uklo.edu.mk/id/eprint/5623

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