The Effect of Chronic Obstructive Pulmonary Disease on Aortic Stiffness

Avramovski, Petar and Avramovska, Maja and Nikolovski, Pece and Sotiroski, Kosta and Sikole, Emilija (2017) The Effect of Chronic Obstructive Pulmonary Disease on Aortic Stiffness. EC Pulmonology and Respiratory Medicine, 4 (2). pp. 59-66.

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Objective: The aim of this study was to compare the aortic stiffness in Chronic Obstructive Pulmonary Disease patients (COPDs) with
the stiffness of the general population patients (GPPs) and to evaluate the determinants of vascular stiffness in COPDs.
Methods: The study group consisted of 93 COPD patients (aged 55.8 ± 10.3 years) and 45 matched control subjects (aged 54.9 ± 8.7
years). Pulse wave velocity (PWV) was assessed from time diversity propagation of the common carotid artery and femoral artery by
Doppler ultrasonography. Biochemical analyses were determined in serum using standard laboratory procedures.
Results: The mean PWV values were: 8.56 ± 2.13 m/s in the COPDs and 7.28 ± 1.45 m/s in the GPPs (p < 0.0001). We found positive
correlation between PWV and COPD duration (r = 0.2729, p = 0.0078). The results of linear regression we present by equation of
simple linear regression: y = 7.548 + 0.06481 ∙ x. By multiple regression analysis, C-reactive protein (CRP) standardized coefficient β
[(βst) = 0.1153, p = 0.0006], COPD duration (βst = 0.06222, p = 0.0164), fibrinogen (βst = 0.3258, p = 0.0493) and triglycerides (βst
= 0.2237, p = 0.2433) were independently associated with PWV in COPDs.
Conclusion: Aortic arterial stiffness was more pronounced in the COPDs than in the GPPs. The independent determinants of arterial
stiffness (PWV) in COPDs include markers of inflammation and triglycerides as traditional risk factor and duration of the chronic
obstructive pulmonary disease.
Keywords: Chronic Obstructive Pulmonary Disease; Pulse Wave Velocity; Aortic Stiffness; Doppler Ultrasonography; Markers of Inflammation;
Traditional Risk Factors

Item Type: Article
Subjects: Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions: UKLO Network
Depositing User: D-r Petar Avramovski
Date Deposited: 27 May 2024 05:55
Last Modified: 27 May 2024 05:55

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