Evaluating the Potential Benefits and Risks of Implementing a Ketogenic Diet in Dementia Patients

Ristevska-Dimitrovska, Gordana and Arsovski, Denis and Ristevski, Jane (2023) Evaluating the Potential Benefits and Risks of Implementing a Ketogenic Diet in Dementia Patients. In: 7th Macedonian Psychiatric Congress, Thematic Conference on Dementia & Neurodegeneration, 26 Oct - 29 Oct 2023, Ohrid, North Macedonia.

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Background: The utilization of ketogenic diets has gained attention as a potential therapeutic approach in various medical conditions. Notably, Alzheimer's disease presents altered glucose metabolism, impaired brain energy production on mitochondria level, disbalance of neurotransmitters function, and heightened inflammation as significant metabolic disruptions.

The objective of this presentation is to present the latest evidence regarding the advantages of ketogenic diets for elderly individuals living with dementia, while also addressing the associated risks and ethical considerations surrounding the implementation of this restrictive dietary regimen.

Results: Drawing from a limited pool of animal studies and clinical trials, ketogenic diets exhibit favorable effects on mitochondrial function and cellular metabolism. They are linked to enhanced cognitive performance in elderly Alzheimer's patients. However, clinical settings warrant careful consideration due to potential risks, including hypoglycemia, dehydration, constipation, nausea, vomiting, and decreased appetite, potentially leading to malnutrition. Additionally, certain behavioral symptoms may intensify, such as initial anxiety and social adjustments necessitated by a lifestyle change. Further investigations are imperative to assess the long-term effects of ketogenic diets on nutritional status, overall well-being, and Alzheimer's disease progression in patients.

Conclusions: The concept of employing ketogenic diets as a novel metabolic intervention in dementia patients holds promise and warrants extensive clinical exploration. This exploration should encompass evaluations of behavioral, physical, and social well-being, with the ultimate goal of prevention and enhancing the quality of life for individuals living with dementia.

Keywords: Ketogenic Diet, Dementia, Alzheimer's Disease

Item Type: Conference or Workshop Item (Speech)
Subjects: Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences
Scientific Fields (Frascati) > Medical and Health Sciences > Other medical sciences
Divisions: Higher Medical School
Depositing User: MSc Denis Arsovski
Date Deposited: 30 Nov 2023 10:55
Last Modified: 30 Nov 2023 10:55
URI: https://eprints.uklo.edu.mk/id/eprint/9364

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