Increased Rate of Chromosomal Abnormalities in PHO Clinical Hospital Bitola in the Period 2018-2020

Ilkovska, Biljana and Kotevska-Trifunova, Bisera and Avramovski, Petar (2022) Increased Rate of Chromosomal Abnormalities in PHO Clinical Hospital Bitola in the Period 2018-2020. EC GYNAECOLOGY, 11 (2). pp. 1-8.

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Abstract

Background: Down’s syndrome and Edwards’ syndrome are the most common chromosomal abnormalities. Prenatal screening is a very important diagnostic tool for the detection of chromosomal abnormalities which is done in the first trimester of the pregnancy between 11 and 14 weeks of gestation.
Methods: In this study we use dual marker test, which is a first-trimester screening test. The markers for this test are PAPP-A (pregnancy-
associated plasma protein-A) and freeβ-hCG (beta human chorionic gonadotropin).
Results: Our study includes 1733 women in a period of three consecutive years (2018-2000). 1597 (92%) of them were negative on the screening, indicating low risk for chromosomal abnormalities, and 136 (8%) women tested positive, indicating increased risk. We concluded that pregnancies with an increased risk of chromosomal abnormality have strong correlation with advanced maternal age. Also, β-hCG is higher in pregnancies with risk, and PAPP-A is lower in pregnancies with increased risk for chromosomal abnormality.
Also, we conclude that rate of pregnancies with increased risk for chromosomal abnormality increased from 5% in 2018 to 11% in 2020 year.
Conclusion: The incidence of chromosomal abnormalities in pregnant women has been growing in the last three years, and these worrying findings impose the need to find out the cause of this phenomenon. The dual marker test is a very important tool for practitioners practitioner, because fetal chromosomal abnormalities can be diagnosed early in gestation and provide enough time for a confirmative test and if the risk of pregnancy is confirmed, it can be terminated in time.
Keywords: PRISCA; PAPP-A; Free Β-Hcg; Chromosomal Abnormalities

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	UKLO Network
Depositing User:	UKLO Mrezha
Date Deposited:	30 Jan 2024 08:03
Last Modified:	30 Jan 2024 08:03
URI:	https://eprints.uklo.edu.mk/id/eprint/9345

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