Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation

Petrovic, Kosta and Djokovic, Radojica and Cincovic, Marko and HRISTOVSKA, TALIJA and Lalovic, Miroslav and PETROVIĆ, MILOŠ and Majkic, Mira and Marinkovic, Maja and Andjusic, Liljana and Devecerski, Gordana and STOJANOVIĆ, DRAGICA and Strbac, Filip Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation. Animals 2022.

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Previous experimental models on cows have examined the difference in the metabolic
adaptation in cows after niacin administration, without identifying the most important mediators
between niacin administration and its biological effects, namely active forms of niacin. All tissues in
the body convert absorbed niacin into its main metabolically active form, the coenzyme nicotinamide
adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The aim of
this study was to determine the influence of niacin administration in periparturient period on NAD,
NADP and the NAD:NADP ratio and to determine relationship between these indicators of an active
form of niacin with metabolic parameters in cow blood. The study included 90 healthy cows: 45 cows
receiving niacin and 45 cows were negative control. The niacin group was treated with nicotinic acid
for two weeks before, as well as two weeks after parturition. Nicotinic acid was applied per os with
feed. In cows receiving niacin, there was a significantly higher concentration of NAD and NADP, but
the NAD:NADP ratio did not differ compared with control. All three indicators were able to separate
cows who received and who did not receive additional niacin. NAD and NADP are good indicators
of the availability of niacin from additional sources. The NAD:NADP ratio is a good indicator of
the biological effect of applied niacin on metabolites in cows due to its correlation with a number
of metabolites: positive correlation with glucose, insulin, glucose to insulin ratio and the revised
quantitative insulin sensitivity check index (RQUICKIBHB) of insulin resistance, triglycerides and
cholesterol, and a negative correlation with nonesterified fatty acid (NEFA), beta hydroxybutyrate
(BHB), gamma-glutamyltranspherase (GGT) and urea in cows receiving niacin. The same amount of
added niacin in feed can produce different concentrations of NAD, NADP and NAD:NADP in the
blood, and this was not related to their concentration before the addition of niacin. The change in the
concentration of the active form of niacin (NAD, NADP and NAD:NADP) further correlates with the concentration of metabolic parameters, which indicates that the intensity of the biological effect of
additional niacin can be accurately determined only if we know the concentrations of its active forms
in blood. Under basal conditions (without additional niacin), active forms of niacin that already exist
in the blood do not show significant correlations with metabolic parameters.
Keywords: cows; niacin; active form; metabolic profile; early lactation

Item Type: Article
Subjects: Scientific Fields (Frascati) > Agricultural Sciences > Veterinary science
Divisions: Faculty of Veterinary Medicine
Depositing User: Mr Aleksandar Lozanovski
Date Deposited: 30 Aug 2023 08:22
Last Modified: 30 Aug 2023 08:22

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