Accelerated progression of arterial stiffness in dialysis patients compared with the general population

Avramovski, Petar and Janakievska, Pavlina and Sotiroski, Kosta and Sikole, Aleksandar (2013) Accelerated progression of arterial stiffness in dialysis patients compared with the general population. Korean Journal of Internal Medicine, 28 (4). pp. 464-474. ISSN 1226-3303

Archive (Impact Factor 3.165) 14. KOREAN J INT MED, Accelerated progression of arterial stiffness....pdf - Accepted Version Download (684kB)

Abstract

Background/Aims: The aim of this study was to compare the progression of aor-
tic stiffness in chronic hemodialysis patients (CHP) with that of general popula-
tion patients (GPP) over a 36-month period and to evaluate the determinants of
this progression.
Methods: The study group included 80 patients undergoing hemodialysis (aged
59.3 ± 11.8 years; duration of dialysis 5.47 ± 5.16 years). The control group consisted
of 60 patients (aged 57.5 ± 10.9 years) with a glomerular filtration rate of > 60 mL/
min/1.73 m2. Pulse wave velocity (PWV) was determined from time diversity prop-
agation of the common carotid artery and femoral artery by Doppler ultrasound.
Clinical and biochemical parameters were determined in serum using standard
laboratory procedures.
Results: The mean PWV values at baseline and 36 months were 11.18 ± 2.29 and
11.82 ± 2.34 m/sec in the CHP group, and 9.02 ± 1.89 and 9.29 ± 1.93 m/sec in the
GPP group, respectively. The average PWV progressions were 63.95 ± 18.373 cm/
sec in CHP and 27.28 ± 28.519 cm/sec in GPP. By multiple regression analysis,
hemoglobin (standardized coefficient β [βst] = -0.405, p = 0.004; βst = -0.364, p =
0.011), albumin (βst = -0.349, p = 0.042; βst = -0.303, p = 0.034), CRP (βst = 0.458, p =
0.002; βst = 0.187, p = 0.008), and total cholesterol (βst = 0.236, p = 0.038; βst = 0.171,
p = 0.078) were independently associated with PWV in the CHP and GPP groups,
respectively.
Conclusions: Accelerated arterial stiffness was more pronounced in the CHP
group than in the GPP group. The independent determinants of this progression
in both groups include traditional risk factors and blood levels of hemoglobin,
albumin and CRP. Cholesterol and uremia-related factors are determinants only
in CHP

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Veterinary Medicine
Depositing User:	D-r Petar Avramovski
Date Deposited:	09 Jun 2023 10:50
Last Modified:	09 Jun 2023 10:50
URI:	https://eprints.uklo.edu.mk/id/eprint/8438

Actions (login required)

View Item