Aortic pulse wave velocity is a strong predictor of all – cause and cardiovascular mortality in chronic dialysis patients

Avramovski, Petar and Janakievska, Pavlina and Sotiroski, Kosta and Zafirova Ivanovska, Beti and Sikole, Aleksandar (2014) Aortic pulse wave velocity is a strong predictor of all – cause and cardiovascular mortality in chronic dialysis patients. Renal Failure, 36 (2). pp. 1-11. ISSN 1525-6049

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15. RENAL FAILURE, Aortic PWV is a strong predictor of all-cause and CV mortality in CHP.pdf - Accepted Version

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Background/Aims: The aim of this study was to investigate all-cause and cardiovascular
mortality in chronic hemodialysis patients (CHP) and to identify the determinants of mortality
predictors. Methods: In this study with 3 years of follow-up period, we studied a cohort of 80
CHPs. Mean age at entry was 59.3�11.8 years (duration of dialysis 5.47�5.16 years). At entry,
together with standard clinical and biochemical analyses, pulse wave velocity (PWV) was
determined from time diversity propagation of the common carotid artery and common
femoral artery flow signals by Doppler ultrasound. Results: The mean PWV (m/s) was presented
at entry: in survived (12.5�2.01) and deceased (13.13�1.70) patients. The PWV cutoff point
(by ROC curves) was 11.8. The regression coefficients (b) and Exp (b) hazard ratio coefficients
of covariates in Cox-regression survival analysis in all-cause and CV outcomes was:
PWV (b¼0.2617, Exp[b]¼1.2992, p¼0.0027; b¼0.3569, Exp[b]¼1.4289, p¼0.0005), CRP
(b¼0.0776, Exp[b]¼1.0807, p¼0.0001; b¼0.0832, Exp[b]¼1.0868, p¼0.0001) and albumin
(b¼�0.1302, Exp[b]¼0.8779, p¼0.0089; b¼�0.1881, 0.8285, p¼0.0030), respectively.
Relative risk for exposed groups according to all-cause and CV events was 4.2976 (95%
CI¼1.6051–11.5071) and 14.3590 (95% CI¼1.6051–11.5071), p¼0.0037, respectively.
Conclusions: We conclude that PWV, CRP and serum albumin are strong independent
predictors of overall and CV mortality in patients undergoing dialysis.

Item Type: Article
Uncontrolled Keywords: Albumin, arterial stiffness, cardiovascular mortality, CRP, survival
Subjects: Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: D-r Petar Avramovski
Date Deposited: 09 May 2023 09:30
Last Modified: 09 May 2023 09:30

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