NEUTROPHIL TO LYMPHOCYTE RATIO AND C-REACTIVE PROTEIN LEVEL IN SEVERE VERSUS NON-SEVERE COVID-19 PATIENTS IN NORTH MACEDONIA

Ilkovska, Biljana and Kotevska-Trifunova, Bisera and Avramovski, Petar (2022) NEUTROPHIL TO LYMPHOCYTE RATIO AND C-REACTIVE PROTEIN LEVEL IN SEVERE VERSUS NON-SEVERE COVID-19 PATIENTS IN NORTH MACEDONIA. ОБЩА МЕДИЦИНА,, 24 (2).

Text 28.====Обшта Медицина Софиа, NLymp ratio and CRP in COVID-19 .pdf Download (980kB)

Abstract

Abstract. Background. Coronavirus disease 2019 (COVID-19) infection is a significant health problem
facing the world community since early 2020. This disease is highly contagious and has a broad spectrum
of clinical manifestations. Aims: This study aimed to investigate NLR and CRP to identify potential clinical
predictors and analyze differences among the severe and non-severe COVID-19 patients. Laboratory
monitoring of certain parameters such as CRP, leukocyte and platelet count is invaluable and crucial for
all cases of COVID-19. Study Design: A single-center retrospective study was conducted on the recruited
patients who were referred to Clinical Hospital, Bitola, North Macedonia, from January to April, 2022. Material
and Methods: Serum CRP level as well as plasma D-dimer level were measured according to standard
methods using Abbott Alinity Ci analyzer. Complete blood counts (white blood cell, neutrophil, lymphocyte
and platelet counts) were measured in EDTA-anticoagulated blood samples using Sysmex XS1000i analyzer
(Sysmex). Afterwards, the NLR value was calculated for each of the patients. Results: Data of 200 patients
(94 female, 106 male) were evaluated. The mean age was 66.63 ± 49.49 years in the group with severe
patients and 51.45 ± 19.01 years in the group of non-severe patients. Compared with the patients with a
non-severe COVID-19 infection, the severe COVID-19 patients had higher levels of CRP, D-dimer, NLR,
platelets, neutrophil count and lower levels of lymphocyte and hemoglobin. In the correlation analysis of NLR
and CLR indices as inflammatory biomarkers in the COVID-19 patients, a positive correlation was observed
between NLR values and CRP in the severe vs non-severe COVID-19. Also, NLR significantly correlated
with D-dimer, hemoglobin and platelets in the severe vs non-severe COVID-19 patients.
Key words: COVID-19, CRP, NLR, neutrophil

Item Type:	Article
Subjects:	Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Veterinary Medicine
Depositing User:	D-r Petar Avramovski
Date Deposited:	13 Apr 2023 12:53
Last Modified:	13 Apr 2023 12:53
URI:	https://eprints.uklo.edu.mk/id/eprint/8011

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