Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women

Avramovski, Petar and Avramovska, Maja (2015) Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women. Anatolian Journal of cardiology, 16 (2). pp. 202-209. ISSN 1302-8723

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Address for Correspondence: Petar Avramovski, MD, PhD, Petar Avramovski, JZU “Clinical Hospital
Dr. Trifun Panovski”, Department of Internal Medicine, 7000 ul. Ivan Milutinovik 37/4-26. Bitola-Republic of Macedonia
Phone: +389 47 243 382 Fax: +389 47 253 435 E-mail: avramovski@gmail.com
Accepted Date: 07.04.2015 Available Online Date: 05.05.2015
©Copyright 2016 by Turkish Society of Cardiology - Available online at www.anatoljcardiol.com
Objective: Osteoporosis and abdominal aortic calcification (AAC) are associated with increased morbidity and mortality in postmenopausal
women. The aim of this study was to determine the accuracy of anterior-posterior (AP) dual-energy X-ray absorptiometry (DXA) compared with
that of X-ray lateral lumbar radiography (LLR) in detecting and scoring AAC.
Methods: In this cross-sectional study conducted in 56 postmenopausal asymptomatic females aged 59.0±9.3 years and who never used
medications to treat osteoporosis before, we determined femoral neck and lumbar spine bone mineral density (BMD) by AP DXA and AAC by
X-ray LLR. We hypothesized that the subtracted femoral neck BMD (BMDFN) from lumbar spine BMD (BMDLS) presented as ΔBMD=BMDLS-
BMDFN would have a diagnostic value in detecting abdominal vascular calcification.
Results: The mean BMDFN was 0.744±0.184 g/cm2, and the mean BMDLS was 0.833±0.157 g/cm2 (p<0.0001); the mean ΔBMD was 0.089±0.077 g/
cm2, and the mean AAC score was 2.182±1.982. Bivariate Pearson’s correlation analysis revealed a significant positive correlation between AAC
and ΔBMD (r=0.449, p=0.0006); by linear regression analysis, R2=0.2019, and by multiple regression analysis, βst=13.5244 (p<0.0001). We found a
sensitivity of 64.3% and specificity of 82.9% by receiver operating characteristic [ROC; area under the ROC curve (AUC=0.759)] in the prediction
of AAC by ΔBMD.
Conclusion: This AP subtracting BMD DXA method provides a useful tool for detecting and scoring subclinical and extensive AAC in postmeno-
pausal women using a simple, semiquantitative, and accurate scoring system with minimal radiation exposure and low cost.
(Anatol J Cardiol 2016; 16: 202-9)
Keywords: aortic diseases, vascular calcification, osteoporosis, postmenopausal, absorptiometry DXA scan, femur neck, lumbar vertebrae

Item Type: Article
Subjects: Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: D-r Petar Avramovski
Date Deposited: 12 Feb 2022 23:57
Last Modified: 12 Feb 2022 23:57
URI: https://eprints.uklo.edu.mk/id/eprint/6814

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