Acute-phase Proteins as Promoters of Abdominal Aortic Calcification in Chronic Dialysis Patients

Avramovski, Petar and Avramovska, Maja and Sotiroski, Kosta and Sikole, Aleksandar (2019) Acute-phase Proteins as Promoters of Abdominal Aortic Calcification in Chronic Dialysis Patients. Saudi J Kidney Diseases Transplantation, 30 (2). pp. 376-386.

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The aim of this study was to find a correlation between acute-phase proteins
(APPs) and abdominal aortic calcification (AAC) as well as the impact APPs on AAC in chronic
dialysis patients (CDPs). Native lateral lumbar radiography and biochemical analysis were
performed in 112 CDPs (aged 60.0 ± 5.43 years) to estimate and score AAC and biochemical
values of APPs. The mean AAC score was 8.39 ± 5.43. We detected 16 (14.28%) CDPs without
AAC and 96 (85.71%) CDPs with AAC (10 ± 5.43). The number of CDPs with AAC ≤4 was 34
(30.36%) with mean AAC score of 1.85 ± 1.94. By multiple regression analysis, we found
positive correlation between AAC and ferritin (β = 0.004398, P = 0.0085) and AAC and Creactive protein [(CRP), β = 0.1972, P = 0.0178]. Sensitivity/specificity pairs and criterion
variables (CrVs) were as follows: for CRP: 44.21%, 100%, and CrV ≥6 and for ferritin: 83.16%,
56.25%, and CrV ≥196.32. The area under curve (AUC) for CRP and ferritin was 0.721 (P
<0.0001) and 0.730 (P <0.0026), respectively. Fibrinogen and serum iron AUC in the prediction
of AAC were 0.533 (P = 0.5749) and 0.618 (P = 0.0795), respectively. CRP and ferritin were the
most powerful APPs involved in the promotion of AAC; serum iron and fibrinogen were shown
as lower activity promoters in CDPs. Serum albumin showed inverse activity on AAC.

Item Type: Article
Subjects: Scientific Fields (Frascati) > Agricultural Sciences > Veterinary science
Divisions: Faculty of Veterinary Medicine
Depositing User: Mr Aleksandar Lozanovski
Date Deposited: 06 May 2021 07:24
Last Modified: 06 May 2021 07:24

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