Avramovska, Maja and Nikleski, Zorica and Avramovski, Petar and Todorovska, Liljana and Talev, Stefan and Stefanovska, Svetlana and Sotiroski, Kosta and Zdraveski, Dejan (2026) Pulse wave velocity as a non-invasive discriminative marker of bone health in postmenopausal women. Caspian Journal of Internal medicine, 17 (3). pp. 622-632. ISSN 2008-6164 / 2008-6172
Preview |
Text
Caspian 2026.pdf Download (1MB) | Preview |
Abstract
Background: Increased arterial stiffness has been linked to osteoporosis. This study evaluates Pulse Wave Velocity (PWV) as a discriminator of osteopenia and osteoporosis at the lumbar spine and femoral neck in postmenopausal women.
Methods: In this cross-sectional study, arterial stiffness and bone mineral density (BMD) at the spine and femoral neck were assessed using carotid-to-femoral Pulse PWV and dual-energy x-ray absorptiometry (DXA). Eighteen premenopausal women (mean age 41.30±4.30 years) and forty-eight postmenopausal women (mean age 59.40±9.10 years) participated in the study. Osteoporosis (T-score ≤-2.5) and osteopenia (-2.5< T-score ≤-1) were defined by T-score criteria.
Results: Pearson's correlation results showed: PWV and femoral neck BMD (r = -0.439, P = 0.002), PWV and spine BMD (r =-0.358, P = 0.012), and PWV and menopausal duration (r = 0.381, P = 0.008). PWV demonstrated significant discriminative ability for femoral neck osteopenia [b = 0.6472, Wald = 5.717, Odds ratio (OR) = 1.910, P = 0.017, Area Under Curve (AUC) = 0.704], femoral neck osteoporosis (b = 0.7206, Wald = 5.838, OR = 2.056, P = 0.016, AUC = 0.758), spine osteopenia (b = 0.8489, Wald = 5.639, OR = 2.337, P = 0.018, AUC = 0.677), and spine osteoporosis (b = 1.0829, Wald = 8.269, OR = 2.953, P = 0.004, AUC = 0.804).
Conclusion: PWV was inversely correlated with femoral neck and spine BMD, and positively correlated with menopausal duration. It serves as a significant discriminator of bone health, indicating increased odds of osteopenia and osteoporosis.
Keywords: Pulse wave velocity, Arterial stiffness, Bone mineral density, Osteoporosis, Dual-energy x-ray absorptiometry, Menopause.
| Item Type: | Article |
|---|---|
| Subjects: | Scientific Fields (Frascati) > Medical and Health Sciences > Basic medicine Scientific Fields (Frascati) > Medical and Health Sciences > Clinical medicine Scientific Fields (Frascati) > Medical and Health Sciences > Health sciences Scientific Fields (Frascati) > Medical and Health Sciences > Other medical sciences |
| Divisions: | UKLO Network |
| Depositing User: | D-r Petar Avramovski |
| Date Deposited: | 04 Nov 2026 11:28 |
| Last Modified: | 04 Nov 2026 11:28 |
| URI: | https://eprints.uklo.edu.mk/id/eprint/11779 |
Actions (login required)
 |
View Item |