ENZIMATIC STATUS IN PATIENTS WITH PANCREATITIS ACUTA

Tuteska, Jovanka and Arapcheska, Mila (2019) ENZIMATIC STATUS IN PATIENTS WITH PANCREATITIS ACUTA. In: INTERNATIONAL BIOLOGICAL, AGRICULTURAL AND LIFE SCIENCE CONGRESS – BIALIC, Lviv, Ukraine.

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Abstract

Pancreatitis acuta is an inflammatory condition of the pancreas. It is commonly caused by biliary tract disease or alcohol abuse. Aim of this study was to analyze the enzymatic status of patients with pancreatitis acuta. In the study were included patients with pancreatitis acuta (n=30; females=14 and males=16). Causes of condition were: biliary tract disease in 53.3% of patients; alcohol abuse (20%), and idiopathic reason (13.3%). Serum and urine samples were taken on admission in the hospital, and at 3th, 7th and 10th day during hospitalization. Changes in concentration of: amylase, lipase, ALT, AST, ALP, GGT and LDH in serum, and amylase and lipase in the urine were analyzed by biochemical analyzer COBAS Integra 400 plus. Obtained results have shown significantly (P<0.01) higher values of analyzed enzymes on patients’ admission in hospital. Concentrations of serum amylase and lipase were 79.15% and 64.68% higher than referent values. In 80% of patients, concentrations of amylase and lipase in urine samples were 32.04% and 70.70% higher than referent. On admission in hospital higher concentrations of ALT (39.66%), were noted in 86.66% of patients; 100% of patients had higher AST values (43.32%); 46.66% had higher ALP values (36.23%). Higher GGT values (60.60%) were noted in 66.66% patients and 60.00% of patients had higher LDH values (15.11%). On 3th day of hospitalization, values of serum amylase and lipase were still significantly higher than referent (P<0.01). Normalization in enzyme concentrations was noted from 7th to 10th day after admission. After 10th day of hospitalization, 93.3% of patients had enzymes values in referent range. Biochemical analysis plays important role in diagnosis of pancreatitis acuta, and most commonly used biochemical markers are serum amylase and lipase.

Item Type: Conference or Workshop Item (Poster)
Subjects: Scientific Fields (Frascati) > Natural sciences > Biological sciences
Scientific Fields (Frascati) > Natural sciences > Other natural sciences
Divisions: Faculty of Biotechnical Sciences
Depositing User: Prof. d-r Mila Arapceska
Date Deposited: 08 Mar 2021 21:12
Last Modified: 08 Mar 2021 21:12
URI: http://eprints.uklo.edu.mk/id/eprint/6297

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