CORRELATION BETWEEN TUMOUR MARKER CA 125 WITH CEA AND CEA 15-3 FOR OVARIAN CANCER DIAGNOSTIC

Tuteska, Jovanka and Arapcheska, Mila and Stojkovski, Velimir and Kosteska, J (2017) CORRELATION BETWEEN TUMOUR MARKER CA 125 WITH CEA AND CEA 15-3 FOR OVARIAN CANCER DIAGNOSTIC. In: 22nd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine "EuroMedLab Athens 2017".

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Abstract

Background: Tumour marker CEA 125 can be used to detect and monitor ovarian cancer. Also, tumour markers CEA and CEA 15-3 can be used as additional parameters. Very often is a trade-off between sensitivity and specificity. Ovarian cancer has the highest death rate among gynaecological cancers. Most ovarian cancers are not detected until a late stage and survival rates than are desperately low. Methods: The study included 20 patients with ovarian cancer. The concentration of tumour markers were measured by IMMULITE 2000 Analyzer. Results: Obtained results have shown significant differences between concentration of tumour markers before and after surgery. The tumour marker CEA 125 is elevated in about 87% of patients with ovarian cancer but only in about 43% of early stage disease. The concentration of CEA 125 before surgery was 125U/ml but after surgery was 110U/ml. The specificity of tumour markers CEA and CEA 15-3 was not significant for diagnostic of ovarian cancer. Conclusions: Tumour markers are valuable diagnostic parameters to support clinical decision making. Specificity of CEA 125 can be very significant and useful for diagnostic and therapy in patients with ovarian cancer. No significant correlation between CEA 125 with CEA and CEA 15-3 was found in this study.

Item Type: Conference or Workshop Item (Poster)
Subjects: Scientific Fields (Frascati) > Natural sciences > Biological sciences
Divisions: Faculty of Biotechnical Sciences
Depositing User: Prof. d-r Mila Arapceska
Date Deposited: 08 Mar 2021 21:11
Last Modified: 08 Mar 2021 21:11
URI: http://eprints.uklo.edu.mk/id/eprint/6289

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