B Group Viramins-Current Uses and Perspectives Chapter: Cincović M., Hristivska T., Belić B.: Niacin, Metabolic Stress and Insulin Resistance in Dairy Cows.

CINCOVIĆ, MARKO and HRISTOVSKA, TALIJA and BELIĆ, BRANISLAVA B Group Viramins-Current Uses and Perspectives Chapter: Cincović M., Hristivska T., Belić B.: Niacin, Metabolic Stress and Insulin Resistance in Dairy Cows. In: B Group Viramins-Current Uses and Perspectives. Intech Open, London, UK, pp. 107-126.

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Official URL: http://dx.doi.org/10.5772/intechopen.72164

Abstract

Metabolic stress in dairy cows occurs around the time of parturition as a consequence ofheightened milk production requirements, accompanied by depressed feed intake anda negative energy balance. Accordingly, the organism enters a state of increased lipolysis,oxidative stress and insulin resistance. Niacin is a well-known antilipolytic vitamin whichenhances gluconeogenesis and insulin concentrations in the blood [1]. A review of the literaturehas revealed that the effect of niacin is dependent upon the dosage administered,pharmaceutical form, duration of administration and biological features of cows [2, 3]. Thereis a limited body of information on the relationship between niacin and insulin productions and efficiency in cows, as well as on the NAD and NADP response to niacin administration.This chapter will elucidate the mechanism of metabolic stress in cows, the pharmacokineticsof niacin, the physiology of the niacin-containing NAD and NADP coenzymes, as well as thebiological effect of niacin on lipolysis, lipolysis-dependent metabolic adaptations and insulinresistance in dairy cows.

Item Type: Book Section
Subjects: Scientific Fields (Frascati) > Agricultural Sciences > Veterinary science
Divisions: Faculty of Veterinary Medicine
Depositing User: Mr Aleksandar Lozanovski
Date Deposited: 04 Apr 2020 17:19
Last Modified: 04 Apr 2020 17:19
URI: http://eprints.uklo.edu.mk/id/eprint/1917

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